Enantiodiscrimination of methamphetamine by circular dichroism using a porphyrin tweezer

Chirality. 2010 May 5;22(4):398-402. doi: 10.1002/chir.20752.

Abstract

Using exciton-coupled circular dichroism (ECCD) spectroscopy, our lab was able to differentiate between the two enantiomers of methamphetamine using a commercially available porphyrin tweezer as an achiral host. The host-guest complex formed with (+)-(S)-methamphetamine produced a negative bisignate-shaped ECCD spectrum, whereas the complex formed with (-)-(R)-methamphetamine produced a positive one. This sensitive technique could serve as an alternative method for the enantiodiscrimination of chiral methamphetamine, a commonly abused drug in the United States.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Chemistry Techniques, Analytical / methods
  • Circular Dichroism / methods*
  • Drug Carriers
  • Magnetic Resonance Spectroscopy
  • Methamphetamine / analysis*
  • Methamphetamine / chemistry*
  • Models, Chemical
  • Molecular Structure
  • Porphyrins / chemistry*
  • Regression Analysis
  • Spectrophotometry, Ultraviolet / methods
  • Stereoisomerism
  • Temperature
  • Ultraviolet Rays

Substances

  • Drug Carriers
  • Porphyrins
  • Methamphetamine