Bone marrow involvement by hodgkin and non-hodgkin lymphomas

Hematol Oncol Clin North Am. 2009 Aug;23(4):873-902. doi: 10.1016/j.hoc.2009.04.014.


Bone marrow evaluation plays a critical role in staging and predicting prognosis in patients with Hodgkin lymphoma or non-Hodgkin lymphoma. Bone marrow can be the initial site of detection of lymphoma in patients with unexplained symptoms or cytopenias. A comprehensive evaluation of bone marrow includes complete blood counts, blood morphology, bone marrow aspirate, and generous core biopsy sections. Specialized testing should be used in a logical fashion on a case by case basis.

Publication types

  • Review

MeSH terms

  • Bone Marrow / immunology
  • Bone Marrow / pathology*
  • Bone Marrow Examination / methods
  • Diagnosis, Differential
  • Flow Cytometry
  • Hodgkin Disease / diagnosis*
  • Hodgkin Disease / immunology
  • Humans
  • Immunophenotyping
  • Lymphoma, Non-Hodgkin / diagnosis*
  • Lymphoma, Non-Hodgkin / immunology
  • Prognosis
  • Reed-Sternberg Cells / immunology
  • Reed-Sternberg Cells / pathology