Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo

Adv Virus Res. 1991;40:181-211. doi: 10.1016/s0065-3527(08)60279-1.


DI viruses and defective viruses generally are widespread in nature. Laboratory studies show that they can sometimes exert powerful disease-modulating effects (either attenuation or intensification of symptoms). Their role in nature remains largely unexplored, despite recent suggestive evidence for their importance in a number of systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Defective Viruses / physiology*
  • Humans
  • Plants / microbiology
  • Virus Physiological Phenomena*
  • Virus Replication
  • Viruses / genetics
  • Viruses / pathogenicity