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, 160 (8), 2467-74

Antibacterial Activity of Hylomecon Hylomeconoides Against Methicillin-Resistant Staphylococcus Aureus

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Antibacterial Activity of Hylomecon Hylomeconoides Against Methicillin-Resistant Staphylococcus Aureus

Jang-Gi Choi et al. Appl Biochem Biotechnol.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is serious clinical urgent problems worldwide. In the present study, the antibacterial activity of Hylomecon hylomeconoides was investigated. The EtOH extract and its fraction (n-hexane, CH(2)Cl(2), EtOAc, and H(2)O) were investigated against MRSA. The most active extract (CH(2)Cl(2)) led to the isolation of 6-methoxydihydrosanguinarine (6-MS), 6-acetonylhydrosanguinarine, and dihydrosanguinarine. These compounds were very active against MRSA strains with minimum inhibitory concentrations (MICs) ranging from 1.95 to 250 microg/ml. Our study did however focus on 6-MS as it appeared to be the most active with MICs in the range of 1.9 to 3.9 microg/ml. These results encourage us to think that 6-MS can be used as a natural antibacterial agent.

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