Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jul;10(7):672-80.

The Role of RAGE in Amyloid-Beta Peptide-Mediated Pathology in Alzheimer's Disease

Affiliations
  • PMID: 19579173
Review

The Role of RAGE in Amyloid-Beta Peptide-Mediated Pathology in Alzheimer's Disease

Ann Marie Schmidt et al. Curr Opin Investig Drugs. .

Abstract

This review discusses current knowledge of the complex interactions between amyloid-beta (A beta) peptide, the receptor for advanced glycation endproducts (RAGE), and inflammatory mediators, focusing on the roles of such interactions in the pathogenesis of Alzheimer's disease. As a ubiquitous cell-surface receptor, RAGE demonstrates enhanced expression in an A beta-rich environment; the effects of RAGE on microglia, the blood-brain barrier and neurons are mediated through various signaling pathways. Relevant preclinical models illustrate that the A beta-RAGE interaction amplifies neuronal stress and the accumulation of A beta, impairs memory and learning, and exaggerates neuroinflammation. These findings suggest that RAGE may mediate a common proinflammatory pathway in neurodegenerative disorders.

Similar articles

See all similar articles

Cited by 39 articles

See all "Cited by" articles

Substances

LinkOut - more resources

Feedback