Congenital tuberculosis after in-vitro fertilisation

Med J Aust. 2009 Jul 6;191(1):41-2. doi: 10.5694/j.1326-5377.2009.tb02676.x.


A 6-week old infant who had been conceived through in-vitro fertilisation (IVF) presented with a skin lesion and enlarged lymph nodes, and developed severe respiratory distress. Mycobacterium tuberculosis was identified; his mother was the only potential source identified. To our knowledge, this is the first case of congenital tuberculosis after IVF reported in Australia and the second worldwide. It highlights the importance of adequate screening during investigation of infertility and the difficulties in diagnosing congenital tuberculosis.

Publication types

  • Case Reports

MeSH terms

  • Antitubercular Agents / therapeutic use
  • Diagnosis, Differential
  • Female
  • Fertilization in Vitro*
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / diagnosis
  • Infant, Newborn, Diseases / drug therapy
  • Infant, Premature*
  • Infectious Disease Transmission, Vertical*
  • Male
  • Mycobacterium tuberculosis / isolation & purification
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Treatment Outcome
  • Tuberculosis, Pulmonary / congenital*
  • Tuberculosis, Pulmonary / diagnosis*
  • Tuberculosis, Pulmonary / drug therapy


  • Antitubercular Agents