Is there variation in crossover interference levels among chromosomes from human males?

Genetics. 2009 Sep;183(1):403-5. doi: 10.1534/genetics.109.103853. Epub 2009 Jul 6.


We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretations of higher levels of interference on shorter chromosomes. We provide appropriate statistical methodology.

MeSH terms

  • Chromosome Mapping / statistics & numerical data
  • Chromosomes, Human / genetics*
  • Crossing Over, Genetic / genetics*
  • Genetic Variation / physiology*
  • Genome, Human
  • Humans
  • Male
  • Meiosis / genetics
  • Sex Factors
  • Statistical Distributions