Vitamin E deficiency has a pathological role in myocytolysis in cardiomyopathic Syrian hamster (BIO14.6)

Biochem Biophys Res Commun. 1991 Nov 27;181(1):145-50. doi: 10.1016/s0006-291x(05)81393-2.


This study revealed the occurrence of vitamin E deficiency in the myocardium of 60-day-old Syrian cardiomyopathic hamsters (BIO14.6), and that this deficiency might be related to the increase in lipid peroxide. Vitamin E administration for ten days effectively restored creatininekinase activity and decreased the lipid peroxide content in the myocardium, returning these to normal control levels (F1b). These results indicate that vitamin E deficiency, possibly combined with oxidative stress in the early cardiomyopathic stage plays an important role in initiating the pathogenesis of myocardial lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiomyopathies / genetics
  • Cardiomyopathies / pathology
  • Cardiomyopathies / physiopathology*
  • Cricetinae
  • Heart / drug effects
  • Lipid Peroxides / metabolism
  • Male
  • Mesocricetus
  • Myocardium / metabolism
  • Myocardium / pathology*
  • Reference Values
  • Vitamin E / metabolism
  • Vitamin E / therapeutic use
  • Vitamin E Deficiency / drug therapy
  • Vitamin E Deficiency / physiopathology*


  • Lipid Peroxides
  • Vitamin E