Chromoendoscopy, narrow-band imaging colonoscopy, and autofluorescence colonoscopy for detection of diminutive colorectal neoplasia in familial adenomatous polyposis

Dis Colon Rectum. 2009 Jun;52(6):1160-5. doi: 10.1007/DCR.0b013e31819ef6fe.


Purpose: This study was designed to compare the diagnostic yield of white light colonoscopy, chromoendoscopy, narrow-band imaging, and autofluorescence imaging in the detection of diminutive lesions.

Methods: Thirteen patients with adenomatous polyposis were examined by total colonoscopy using an instrument that incorporated both narrow-band and autofluorescence imaging. Colonoscopic images were obtained using white light colonoscopy, autofluorescence imaging, narrow-band imaging, and chromoendoscopy. All images were captured at equivalent angles and distances from the colorectal mucosa.

Results: Chromoendoscopy detected the greatest number of lesions at all sites within the large intestine, and it detected a significantly greater number than the other procedures on the left side of the large intestine. Narrow-band imaging depicted a greater number of lesions than did white light in the transverse colon, descending colon, and rectum. Autofluorescence imaging showed a greater number of lesions than did white light in the rectum. The total number of depicted lesions under chromoendoscopy (43.3 +/- 38.5) was significantly greater than the total number detected with white light (12.2 +/- 13.9, P = 0.005), autofluorescence imaging (21.4 +/- 27.5, P = 0.0006), and narrow-band imaging (20.1 +/- 21.5, P = 0.003). Narrow-band imaging detected a significantly higher total number of lesions than did white light (P = 0.04).

Conclusion: Chromoendoscopy is superior to white light colonoscopy, autofluorescence imaging, and narrow-band imaging for detection of diminutive colorectal lesions in adenomatous polyposis.

Publication types

  • Comparative Study

MeSH terms

  • Adenoma / diagnosis
  • Adenomatous Polyposis Coli / diagnosis*
  • Adenomatous Polyposis Coli / pathology
  • Adolescent
  • Adult
  • Colonoscopes
  • Colonoscopy / methods*
  • Colorectal Neoplasms / diagnosis*
  • Colorectal Neoplasms / pathology
  • Coloring Agents
  • Cross-Sectional Studies
  • Diagnosis, Differential
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Microscopy, Fluorescence / methods*
  • Middle Aged
  • Precancerous Conditions / diagnosis*
  • Precancerous Conditions / pathology


  • Coloring Agents