Axon regeneration in the peripheral and central nervous systems

Results Probl Cell Differ. 2009:48:339-51. doi: 10.1007/400_2009_19.


Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. Consequently, functional deficits persist after spinal cord injury (SCI), traumatic brain injury, stroke, and related conditions that involve axonal disconnection. This situation differs from that in the mammalian peripheral nervous system (PNS), where long-distance axon regeneration and substantial functional recovery can occur in the adult. Both extracellular molecules and the intrinsic growth capacity of the neuron influence regenerative success. This chapter discusses determinants of axon regeneration in the PNS and CNS.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Central Nervous System / physiology*
  • Chondroitin Sulfate Proteoglycans / metabolism
  • Cornified Envelope Proline-Rich Proteins / genetics
  • Cornified Envelope Proline-Rich Proteins / metabolism
  • Humans
  • Nerve Regeneration*
  • Peripheral Nervous System / physiology*
  • Signal Transduction


  • Chondroitin Sulfate Proteoglycans
  • Cornified Envelope Proline-Rich Proteins
  • SPRR1A protein, human