A new view of prostaglandin E regulation of the immune response

Immunol Today. 1991 Oct;12(10):349-52. doi: 10.1016/0167-5699(91)90064-Z.


Prostaglandins, particularly those of the E series, are widely regarded as immunosuppressive products of eukaryotic cells that can downregulate many aspects of B- and T-cell function. In this article, Richard Phipps and colleagues present a different concept of E series prostaglandins, based on recent evidence supporting a role for prostaglandins as potentiators of immunoglobulin class switching and of the synthesis of selected cytokines and cytokine receptors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antibody Formation / immunology*
  • B-Lymphocytes / immunology
  • Cytokines / biosynthesis
  • Humans
  • Immunoglobulin Switch Region / immunology*
  • Immunoglobulins / immunology*
  • Prostaglandins E / immunology*
  • Receptors, Immunologic / biosynthesis
  • T-Lymphocytes / immunology


  • Cytokines
  • Immunoglobulins
  • Prostaglandins E
  • Receptors, Immunologic