Modulation of T-cell function by gliomas

Immunol Today. 1991 Oct;12(10):370-4. doi: 10.1016/0167-5699(91)90068-5.


Patients with primary intracranial tumors (gliomas) exhibit a profound decrease in immunity, the mechanism of which has, until recently, remained obscure. Here Thomas Roszman, Lucinda Elliott and William Brooks reveal that T cells obtained from these patients exhibit defects in interleukin 2 secretion and in expression of the high-affinity IL-2 receptor and they discuss the role played by immunosuppressive factors produced by gliomas in inducing these defects.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms / immunology*
  • Glioma / immunology*
  • Humans
  • Interleukin-2 / metabolism
  • Lymphocyte Activation / immunology
  • Receptors, Interleukin-2 / metabolism
  • T-Lymphocytes / immunology*
  • Transforming Growth Factor beta / immunology
  • Transforming Growth Factor beta / isolation & purification


  • Interleukin-2
  • Receptors, Interleukin-2
  • Transforming Growth Factor beta