Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention

Cell Metab. 2009 Jul;10(1):1-2. doi: 10.1016/j.cmet.2009.06.005.


In this issue of Cell Metabolism, Kaufman and colleagues (Back et al., 2009) elegantly demonstrate that appropriate regulation of eIF2alpha phosphorylation improves glucose tolerance and beta cell viability by preventing the lethal buildup of oxidative damage due to unregulated synthesis, trafficking, and misfolding of proteins.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Diabetes Mellitus, Type 2 / prevention & control
  • Eukaryotic Initiation Factor-2 / genetics
  • Eukaryotic Initiation Factor-2 / metabolism*
  • Insulin-Secreting Cells / metabolism*
  • Mice
  • Oxidative Stress
  • Phosphorylation


  • Antioxidants
  • Eukaryotic Initiation Factor-2