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, 125 (10), 2413-7

Coffee Drinking and Risk of Endometrial Cancer--A Population-Based Cohort Study

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Coffee Drinking and Risk of Endometrial Cancer--A Population-Based Cohort Study

Emilie Friberg et al. Int J Cancer.

Abstract

Coffee drinking has been reported to have beneficial effects on insulin resistance, which has been directly associated with endometrial cancer. Although a relationship between coffee consumption and endometrial cancer risk is biologically plausible, this hypothesis has been previously explored in only 2 prospective studies, with a small number of cases. We used data from the Swedish Mammography Cohort, a population-based prospective cohort study of 60,634 women. During 17.6 years of follow-up, 677 participants were diagnosed with incident endometrial cancer (adenocarcinoma). We examined the association between self-reported coffee consumption (at baseline 1987-90 and in 1997) and endometrial cancer risk using Cox proportional hazards models. Each additional cup (200 g) of coffee per day was associated with a rate ratio (RR) of 0.90 [95% confidence interval (CI), 0.83-0.97]. In women drinking 4 or more cups of coffee a day, the RR for the risk reduction of endometrial cancer was 0.75 (95% CI, 0.58-0.97) when compared with those who drank 1 cup or less. The association seemed largely confined to overweight and obese women, who showed a respective risk reduction of 12% (95% CI, 0-23%) and 20% (95% CI, 7-31%) for every cup of coffee, but was not observed among normal-weight women. There was a statistically significant interaction between coffee consumption and body mass index (p(interaction) < 0.001). These data indicate that coffee consumption may be associated with decreased risk of endometrial cancer, especially among women with excessive body weight. If confirmed by other prospective studies, these results are of major public health significance.

Figures

Figure 1
Figure 1
Rate ratios (RRs) and 95% CIs of coffee consumption among women in the Swedish Mammography Cohort at baseline in relation to endometrial cancer risk using restricted cubic splines. Multivariable adjusted rate ratios for coffee consumption in relation to endometrial cancer incidence adjusted for age, BMI and smoking. Plot of the restricted cubic splines (solid line), linear trend (long-dash line), and dotted lines 95% confidence limits of the linear trend.
Figure 2
Figure 2
Associations of coffee consumption stratified by BMI in relation to endometrial cancer for women in the Swedish Mammography Cohort. Rate ratios (RR) from Cox proportional hazards models adjusted for age and smoking. Pinteraction <0.001 All Pvalues from RRs were <0.05.

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