Oral food challenge in children: an expert review

Eur Ann Allergy Clin Immunol. 2009 Apr;41(2):35-49.


Oral food challenges are indicated for the diagnosis of food allergy and the double-blind, placebo-controlled oral food challenge is considered the gold standard diagnostic method in children with suspected food allergy. This practice parameter for oral food challenges in children was prepared by a workgroup at the request of the French Society for Allergology and Clinical Immunology (SFAIC) and the French Paediatric Society for Allergology and Pulmonology (SP2A). We aimed to develop practical guidelines for oral food challenges in children for the diagnosis of suspected food allergy or the evaluation of food tolerance. We also considered the safety measures to be implemented during testing and management of the potentially serious allergic reactions that may arise during the test. The strength of the recommendations was established, using the GRADE evidence-based approach. We considered four issues: (1) the selection of children for oral food challenges (indications and contraindications); (2) the procedure used (material, where the test should be carried out, technique and management of reactions); (3) interpretation of the test and (4) consequences of the test.

Publication types

  • Consensus Development Conference
  • Practice Guideline

MeSH terms

  • Administration, Oral
  • Allergens / administration & dosage*
  • Allergens / adverse effects
  • Allergens / immunology
  • Child
  • Contraindications
  • Diagnostic Techniques and Procedures / adverse effects
  • Diagnostic Techniques and Procedures / standards*
  • Double-Blind Method
  • Food Hypersensitivity / diagnosis*
  • Food Hypersensitivity / immunology
  • Humans
  • Hypersensitivity / drug therapy
  • Hypersensitivity / immunology
  • Immunoglobulin E / blood
  • Immunoglobulin E / immunology
  • Skin Tests


  • Allergens
  • Immunoglobulin E