Anti-listerial activity and structure-activity relationships of the six major tyrocidines, cyclic decapeptides from Bacillus aneurinolyticus

Bioorg Med Chem. 2009 Aug 1;17(15):5541-8. doi: 10.1016/j.bmc.2009.06.029. Epub 2009 Jun 21.


Six major tyrocidines, purified from the antibiotic tyrothricin complex produced by Bacillus aneurinolyticus, showed significant lytic and growth inhibitory activity towards the gram+ bacteria, Micrococcus luteus and Listeria monocytogenes, but not against the gram- bacterium, Escherichia coli. The isolated natural tyrocidines were in particular more active against the leucocin A (antimicrobial peptide) resistant strain, L. monocytogenes B73-MR1, than the sensitive L. monocytogenes B73 strain. Remarkably similar structure-activity trends toward the three gram+ bacteria were found between growth inhibition and different physicochemical parameters (solution amphipathicity, theoretical lipophilicity, side-chain surface area and mass-over-charge ratio).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / analysis*
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus / metabolism*
  • Bacteria / drug effects
  • Bacteria / growth & development
  • Listeria monocytogenes / drug effects*
  • Listeria monocytogenes / growth & development
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Structure-Activity Relationship
  • Tyrocidine / analysis*
  • Tyrocidine / pharmacology*


  • Anti-Bacterial Agents
  • Tyrocidine