Introducing intermediate filaments: from discovery to disease

J Clin Invest. 2009 Jul;119(7):1763-71. doi: 10.1172/JCI38339. Epub 2009 Jul 1.


It took more than 100 years before it was established that the proteins that form intermediate filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in virtually all differentiated cells and present both in the cytoplasm and in the nucleus. However, during the past 2 decades, knowledge regarding the functions of these structures has been expanding rapidly. Many disease-related roles of IFs have been revealed. In some cases, the molecular mechanisms underlying these diseases reflect disturbances in the functions traditionally assigned to IFs, i.e., maintenance of structural and mechanical integrity of cells and tissues. However, many disease conditions seem to link to the nonmechanical functions of IFs, many of which have been defined only in the past few years.

Publication types

  • Review

MeSH terms

  • 14-3-3 Proteins / physiology
  • Animals
  • Cell Movement
  • Cytoprotection
  • Humans
  • Intermediate Filament Proteins / analysis
  • Intermediate Filament Proteins / physiology
  • Intermediate Filaments / classification
  • Intermediate Filaments / physiology*
  • Signal Transduction
  • Vimentin / physiology


  • 14-3-3 Proteins
  • Intermediate Filament Proteins
  • Vimentin