Abstract
Hypoxia-activated pro-oligonucleotides were synthesized through the commercial phosphoramidite method, and could be readily cleaved to form normal oligos with good hypoxia selectivity in vitro under the effect of reductases, as well as in tumor cell extract.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Base Sequence
-
Cattle
-
Drug Design*
-
Escherichia coli / enzymology
-
Fluorescein / metabolism
-
HeLa Cells
-
Humans
-
Hypoxia*
-
Nitroreductases / metabolism
-
Oligonucleotides / chemical synthesis*
-
Oligonucleotides / chemistry
-
Oligonucleotides / genetics
-
Oligonucleotides / metabolism*
-
Prodrugs / chemical synthesis*
-
Prodrugs / chemistry
-
Prodrugs / metabolism*
-
Staining and Labeling
Substances
-
Oligonucleotides
-
Prodrugs
-
Nitroreductases
-
Fluorescein