Intravascular large B-cell lymphoma of the skin: typical clinical manifestations and a favourable response to rituximab-containing therapy

Dermatology. 2009;219(4):344-6. doi: 10.1159/000228328. Epub 2009 Jul 8.

Abstract

Intravascular large B-cell lymphoma (IVBCL) is a rare malignant neoplasm characterized by the proliferation of large B cells within the blood vessels. The disease can be limited to the skin, but involvement of other organs is common. We report a case of cutaneous IVBCL in a 62-year-old man with minimal histological changes in contrast to prominent skin lesions. The patient was successfully treated with rituximab in combination with CHOP chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Biopsy
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / diagnosis
  • Lymphoma, Large B-Cell, Diffuse / drug therapy*
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Male
  • Middle Aged
  • Prednisolone / administration & dosage
  • Rituximab
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology*
  • Thoracic Wall / pathology
  • Treatment Outcome
  • Vascular Neoplasms / diagnosis
  • Vascular Neoplasms / drug therapy*
  • Vascular Neoplasms / pathology*
  • Vincristine / administration & dosage

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Rituximab
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisolone