Distinct neuroinflammatory profile in post-mortem human Huntington's disease

Neuroreport. 2009 Aug 5;20(12):1098-103. doi: 10.1097/WNR.0b013e32832e34ee.

Abstract

Neuroinflammation is a prominent feature of many neurodegenerative diseases, however, little is known about neuroinflammation in Huntington's disease. We used quantitative real time-PCR to compare the expression level of neuroinflammation-associated mediators in the striatum, cortex, and cerebellum from post-mortem Huntington's disease patient samples with controls. We found increased expression of several key inflammatory mediators, including CCL2 and IL-10, specifically in the striatum of Huntington's disease patients, the main area affected by this pathology. Remarkably, we also found upregulation of IL-6, IL-8, and MMP9, in the cortex and notably the cerebellum, a brain area commonly thought to be spared by Huntington's disease. Our data suggest that neuroinflammation is a prominent feature associated with Huntington's disease and may constitute a novel target for therapeutic intervention.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cerebellum / immunology*
  • Cerebellum / metabolism
  • Cerebral Cortex / immunology*
  • Cerebral Cortex / metabolism
  • Chemokine CCL2 / genetics
  • Chemokine CCL2 / metabolism
  • Corpus Striatum / immunology*
  • Corpus Striatum / metabolism
  • Female
  • Gene Expression
  • Humans
  • Huntington Disease / genetics
  • Huntington Disease / immunology*
  • Huntington Disease / metabolism
  • Interleukin-10 / genetics
  • Interleukin-10 / metabolism
  • Interleukin-1beta / genetics
  • Interleukin-1beta / metabolism
  • Interleukin-6 / genetics
  • Interleukin-6 / metabolism
  • Interleukin-8 / genetics
  • Interleukin-8 / metabolism
  • Male
  • Matrix Metalloproteinase 9 / genetics
  • Matrix Metalloproteinase 9 / metabolism
  • Middle Aged
  • RNA, Messenger / metabolism
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • CCL2 protein, human
  • Chemokine CCL2
  • IL10 protein, human
  • IL6 protein, human
  • Interleukin-1beta
  • Interleukin-6
  • Interleukin-8
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Matrix Metalloproteinase 9