Power to Detect the Effects of HIV Vaccination in Repeated Low-Dose Challenge Experiments

J Infect Dis. 2009 Aug 15;200(4):609-13. doi: 10.1086/600891.

Abstract

Simulation studies were conducted to estimate the statistical power of repeated low-dose challenge experiments performed in nonhuman primates to detect the effect of a candidate human immunodeficiency virus vaccine. The effect of various design parameters on power was explored. Results of simulation studies indicate that repeated low-dose challenge studies with a total sample of size 50 (25 animals/arm) typically provide adequate power to detect a 50% reduction in the per-exposure probability of infection resulting from vaccination. Power generally increases with the maximum number of allowable challenges per animal, the per-exposure risk of infection in control animals, and the proportion of animals susceptible to infection.

MeSH terms

  • AIDS Vaccines / immunology*
  • Animals
  • Computer Simulation*
  • Data Interpretation, Statistical*
  • Humans
  • Models, Biological*
  • Models, Statistical
  • Research Design

Substances

  • AIDS Vaccines