Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease

Acta Neurobiol Exp (Wars). 2009;69(2):232-53.

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Chromosome missegregation was proposed two decades ago to be responsible for neurodegeneration in AD patients. It was speculated that the aneuploidy is a result of aberrant cell cycle of neuronal progenitors during adult neurogenesis and/or of mature neurons. There is mounting evidence of increased rate of general aneuploidy and cell cycle reentry in the AD patients' brains, with area-specific pattern. In this review, we discuss the involvement of chromosome instability, genome damage and cell cycle impairment in AD pathology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease* / genetics
  • Alzheimer Disease* / pathology
  • Alzheimer Disease* / physiopathology
  • Amyloid beta-Peptides / metabolism
  • Aneuploidy*
  • Animals
  • Brain / pathology*
  • Brain / physiopathology
  • Cell Cycle / physiology*
  • Chromosomes / genetics*
  • Genetic Predisposition to Disease
  • Humans
  • tau Proteins / metabolism

Substances

  • Amyloid beta-Peptides
  • tau Proteins