Calorie restriction alters mitochondrial protein acetylation

Aging Cell. 2009 Sep;8(5):604-6. doi: 10.1111/j.1474-9726.2009.00503.x. Epub 2009 Jul 9.


Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue-specific fashion. Via large-scale mass spectrometry screening, we identify 72 candidate proteins involved in a variety of metabolic pathways with altered acetylation during CR. Mitochondrial acetylation changes may play an important role in the pro-longevity CR response.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Animals
  • Caloric Restriction / statistics & numerical data*
  • Humans
  • Life Expectancy
  • Longevity / physiology*
  • Mammals / growth & development
  • Mammals / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Mitochondria / metabolism*
  • Mitochondria, Liver / metabolism*
  • Proteins / metabolism*
  • Saccharomycetales / growth & development
  • Saccharomycetales / physiology*


  • Proteins