Combining Transbronchial Biopsy Using Endobronchial Ultrasonography With a Guide Sheath and Positron Emission Tomography for the Diagnosis of Small Peripheral Pulmonary Lesions

Lung Cancer. 2010 May;68(2):211-5. doi: 10.1016/j.lungcan.2009.06.004.

Abstract

To evaluate the combination of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS) and positron emission tomography with fluorodeoxyglucose (FDG-PET) for the diagnosis of small peripheral pulmonary lesions (PPLs) < or = 30 mm in mean diameter. A total of 74 PPLs (69.2%) were diagnosed by TBB using EBUS-GS with X-ray fluoroscopy. Diagnostic yield by FDG-PET was 78.5% for the 107 PPLs examined. Diagnostic yield with the combination of TBB using EBUS-GS and FDG-PET (90.7%) was significantly higher compared with that for each procedure alone. A significant increment in diagnostic yield with this combination was seen for PPLs >20mm and < or = 30 mm and for malignant lesions. Combination of TBB using EBUS-GS and FDG-PET is useful for the diagnosis of small PPLs.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / physiopathology
  • Aged
  • Biopsy
  • Bronchi / diagnostic imaging
  • Bronchi / pathology*
  • Bronchography*
  • Carcinoma, Squamous Cell / diagnosis*
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / physiopathology
  • Diagnosis, Differential
  • Endosonography
  • Humans
  • Image Interpretation, Computer-Assisted / methods
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / physiopathology
  • Male
  • Middle Aged
  • Multiple Pulmonary Nodules / diagnosis*
  • Multiple Pulmonary Nodules / pathology
  • Multiple Pulmonary Nodules / physiopathology
  • Positron-Emission Tomography
  • Pulmonary Disease, Chronic Obstructive / diagnosis*
  • Pulmonary Disease, Chronic Obstructive / pathology
  • Pulmonary Disease, Chronic Obstructive / physiopathology