Dysfunction of the Default Mode Network in Parkinson Disease: A Functional Magnetic Resonance Imaging Study

Arch Neurol. 2009 Jul;66(7):877-83. doi: 10.1001/archneurol.2009.97.


Objective: To examine the integrity of the default mode network in patients with Parkinson disease (PD). Previous functional neuroimaging experiments have studied executive deficits in patients with PD with regard to task-related brain activation. However, recent studies suggest that executive performance also relies on the integrity of the default mode network (ie, medial prefrontal cortex, posterior cingulate cortex, precuneus, and lateral parietal and medial temporal cortices), characterized by a deactivation of these cortical areas during the performance of executive tasks.

Design: We used functional magnetic resonance imaging to investigate cortical deactivations during a card-sorting task (retrieval and manipulation of short-term memory contents) compared with a simple sensory-motor matching task. In addition, a functional connectivity analysis was performed.

Setting: Tertiary outpatient clinic.

Participants: Seven patients with mild to moderate PD (not taking medication) and 7 healthy controls.

Main outcome measure: Cortical deactivations.

Results: Both groups showed comparable deactivation of the medial prefrontal cortex but different deactivation in the posterior cingulate cortex and the precuneus. Compared with controls, patients with PD not only showed less deactivation of the posterior cingulate cortex and the precuneus, they even demonstrated a reversed pattern of activation and deactivation. Connectivity analysis yielded that in contrast to healthy individuals, medial prefrontal cortex and the rostral ventromedial caudate nucleus were functionally disconnected in PD.

Conclusions: We describe specific malfunctioning of the default mode network during an executive task in PD. This finding is plausibly linked to dopamine depletion and may critically contribute to the understanding of executive deficits in PD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain Mapping*
  • Cerebral Cortex / blood supply*
  • Cerebral Cortex / physiopathology
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Nerve Net / blood supply
  • Nerve Net / pathology
  • Neural Pathways / blood supply*
  • Neural Pathways / pathology
  • Neural Pathways / physiopathology
  • Neuropsychological Tests
  • Oxygen / blood
  • Parkinson Disease / pathology*
  • Parkinson Disease / physiopathology
  • Problem Solving / physiology
  • Statistics as Topic


  • Oxygen