Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Nat Genet. 2009 Aug;41(8):879-81. doi: 10.1038/ng.416. Epub 2009 Jul 13.

Abstract

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

MeSH terms

  • Atrial Fibrillation / genetics*
  • Chromosomes, Human, Pair 16 / genetics
  • European Continental Ancestry Group / genetics*
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Homeodomain Proteins / genetics*
  • Humans
  • Meta-Analysis as Topic
  • Mutation / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Reproducibility of Results

Substances

  • Homeodomain Proteins
  • ZFHX3 protein, human

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