Yohimbine does not affect fat distribution in men

Int J Obes. 1991 Sep;15(9):561-5.


Forty-seven men with a mean age of 42 years were assigned in random, double-blind fashion to treatment with either placebo or high-dose yohimbine (peak dose, 43 mg/day). Thirty-three subjects completed the six-month program. Variables assessed throughout the study included: body weight and body mass index; total cholesterol and HDL; body fat; and fat distribution as measured both by waist-to-hip ratio and by CT scan. Treatment with yohimbine had no effect on any variable in comparison with the control group.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / anatomy & histology
  • Adipose Tissue / drug effects*
  • Administration, Oral
  • Adult
  • Analysis of Variance
  • Body Mass Index
  • Double-Blind Method
  • Humans
  • Lipolysis
  • Male
  • Middle Aged
  • Obesity / drug therapy*
  • Patient Compliance
  • Skinfold Thickness
  • Tomography, X-Ray Computed
  • Weight Loss / drug effects
  • Yohimbine / administration & dosage
  • Yohimbine / pharmacology
  • Yohimbine / therapeutic use*


  • Yohimbine