Wound healing activity of flower extract of Calendula officinalis

J Basic Clin Physiol Pharmacol. 2009;20(1):73-9. doi: 10.1515/jbcpp.2009.20.1.73.


The effects of oral and topical application of Calendula officinalis flower extract on excision wounds made in rats were checked. The parameters assessed were the days needed for re-epithelization and percentage of wound closure. The hydroxy proline and hexosamine content in the granuloma tissue of the wound was also measured. The percentage of wound closure was 90.0% in the extract-treated group, whereas the control group showed only 51.1% on the eighth day of wounding (p < .01). The days needed for re-epithelization were 17.7 for the control animals; extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period to 14 and 13 days, respectively. A significant increase was observed in the hydroxy proline and hexosamine content in the extract-treated group compared with the untreated animals. The data indicate potent wound healing activity ofC. officinalis extract.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Calendula* / chemistry
  • Carotenoids / pharmacology
  • Female
  • Flowers
  • Hexosamines / analysis
  • Hydroxyproline / analysis
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Wound Healing / drug effects*


  • Antioxidants
  • Hexosamines
  • Plant Extracts
  • Carotenoids
  • Hydroxyproline