Pharmacokinetics in special populations

Drug Metab Rev. 2009;41(3):422-54. doi: 10.1080/10837450902891527.


Pharmacokinetics are typically dependent on a variety of physiological variables (e.g., age, ethnicity, or pregnancy) or pathological conditions (e.g., renal and hepatic insufficiency, cardiac dysfunction, obesity, etc.). The influence of some of these conditions has not always been thoroughly assessed in the clinical studies of antiallergic drugs. However, the knowledge of the physiological grounds of the pharmacokinetics can provide some insight for predicting the potential alterations and guiding the initial prescription strategies. It is important to recognize that both pharmacokinetic and pharmacodynamic differences between populations should be considered. The available information on drugs used for the therapy of allergic diseases is reviewed in this chapter.

Publication types

  • Review

MeSH terms

  • Adult
  • Age Factors
  • Animals
  • Anti-Allergic Agents / pharmacokinetics*
  • Anti-Allergic Agents / pharmacology
  • Anti-Allergic Agents / therapeutic use
  • Child
  • Heart Diseases / complications
  • Heart Diseases / metabolism
  • Hepatic Insufficiency / complications
  • Hepatic Insufficiency / metabolism
  • Humans
  • Hypersensitivity / complications
  • Hypersensitivity / drug therapy
  • Hypersensitivity / metabolism*
  • Inactivation, Metabolic
  • Obesity / complications
  • Obesity / metabolism
  • Renal Insufficiency / complications
  • Renal Insufficiency / metabolism


  • Anti-Allergic Agents