Sex steroid and tropic hormone levels may be associated with postoperative prognosis of vitrectomy in Korean postmenopausal women: a pilot study

Menopause. 2010 Jan-Feb;17(1):161-5. doi: 10.1097/gme.0b013e3181aa2734.

Abstract

Objective: The aim of this study was to evaluate the postoperative prognostic value of sex hormones and related biochemical markers for vitrectomy in postmenopausal Korean women.

Methods: Twenty-three postmenopausal women undergoing vitrectomy who had not received hormone therapy were recruited. Before vitrectomy, hormonal profile such as follicle-stimulating hormone, estradiol, testosterone, tumor markers, and biochemical markers including homocysteine, glycosylated hemoglobin, protein, albumin, and lipid panel was measured. These parameters were correlated with ophthalmologic outcomes such as intraocular pressure, preoperative and postoperative visual acuity, and the visual improvement after surgery.

Results: Follicle-stimulating hormone showed a positive correlation with the logarithm of the minimal angle of resolution value of postoperative visual acuity (Pearson's correlation, 0.583; P = 0.009). This significance was maintained after age or preoperative visual acuity was adjusted (P = 0.006 and P = 0.013, respectively). Testosterone also showed a positive correlation with intraocular pressure before and after adjustment for age (P = 0.027 and P = 0.033, respectively).

Conclusions: Sex steroid and tropic hormones may be associated with postoperative ophthalmologic outcomes in the postmenopausal women undergoing vitrectomy. Further larger scale studies will be necessary to confirm these preliminary results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Dehydroepiandrosterone / blood
  • Estradiol / blood
  • Female
  • Follicle Stimulating Hormone, Human / blood*
  • Humans
  • Intraocular Pressure
  • Korea
  • Middle Aged
  • Pilot Projects
  • Postmenopause / blood*
  • Prognosis
  • Recovery of Function*
  • Testosterone / blood*
  • Thyrotropin / blood*
  • Visual Acuity
  • Vitrectomy / rehabilitation*
  • alpha-Fetoproteins / analysis

Substances

  • Follicle Stimulating Hormone, Human
  • alpha-Fetoproteins
  • Testosterone
  • Dehydroepiandrosterone
  • Estradiol
  • Thyrotropin