Mammalian polyamine metabolism and function

IUBMB Life. 2009 Sep;61(9):880-94. doi: 10.1002/iub.230.


Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize the current state of understanding of polyamine metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biogenic Polyamines / metabolism
  • Biogenic Polyamines / physiology*
  • Mammals


  • Biogenic Polyamines