Glutamine as precursor for the GABA and glutamate trasmitter pools

J C Reubi; C Van Der Berg; M Cuénod

doi:10.1016/0304-3940(78)90030-7

Glutamine as precursor for the GABA and glutamate trasmitter pools

Neurosci Lett. 1978 Nov;10(1-2):171-4. doi: 10.1016/0304-3940(78)90030-7.

Authors

J C Reubi¹, C Van Der Berg, M Cuénod

Affiliation

¹ Brain Research Institute, University of Zürich, August Forelstrasse 1, 8029 Zürich, Switzerland.

PMID: 19605275
DOI: 10.1016/0304-3940(78)90030-7

Abstract

Pigeon optic tectum slices were incubated in [(3)H] glutamine in order to label the glutamate and GABA pools. 47 mM potassium chloride induced a calcium-dependent release of [(3)H] glutamate and [(3)H] GABA. This indicates that glutamine is an efficient precursor of the releasable glutamate and GABA pools and supports the view that both amino acids play a role as neurotransmitters in the optic tectum.