Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance

Am J Chin Med. 2009;37(3):557-72. doi: 10.1142/S0192415X09007053.


We explored the effects and mechanisms of Rhodiola rosea extract supplementation on swimming-induced fatigue in rats. The concentrations of active components in Rhodiola rosea have been determined by high performance liquid chromatography-mass spectrometer. The Rhodiola rosea extract supplementation in water for 2-4 weeks was evaluated in male Wistar rats with 90-min unloaded swimming exercise and 5% body weight loaded swimming up to fatigue. We measured the fatigue biomarkers, including blood urea nitrogen (BUN), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LDH), hepatic glycogen content, the activity of fat metabolism enzymes, sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS), the tissue oxygen content and ratio of red and white skeletal muscle fibers in rats. Rhodiola rosea significantly increased liver glycogen, SREBP-1, FAS, heat shock protein 70 expression, Bcl-2/Bax ratio and oxygen content before swimming. Rhodiola rosea supplementation significantly increased the swimming time in a dose-dependent manner and reduced swimming-enhanced serum BUN, GOT and GPT levels. The ratio of red and white muscle fibers was not altered after chronic Rhodiola rosea extract supplementation. Chronic Rhodiola rosea supplementation significantly improved exhaustive swimming-induced fatigue by the increased glycogen content, energy supply of lipogenic enzyme expressions and protective defense mechanisms.

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Biomarkers / metabolism
  • Drugs, Chinese Herbal / pharmacology*
  • Fatigue / drug therapy*
  • Fatigue / metabolism
  • HSP70 Heat-Shock Proteins / metabolism
  • Liver Glycogen / metabolism
  • Male
  • Muscle Fibers, Skeletal / drug effects
  • Muscle Fibers, Skeletal / metabolism
  • Muscle, Skeletal / cytology
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / physiology
  • Oxidative Stress / drug effects
  • Physical Conditioning, Animal
  • Physical Endurance / drug effects*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Rats
  • Rats, Wistar
  • Rhodiola*
  • Sterol Regulatory Element Binding Protein 1 / metabolism
  • Swimming / physiology*
  • bcl-2-Associated X Protein / metabolism
  • fas Receptor / metabolism


  • Bax protein, rat
  • Biomarkers
  • Drugs, Chinese Herbal
  • Fas protein, rat
  • HSP70 Heat-Shock Proteins
  • Liver Glycogen
  • Proto-Oncogene Proteins c-bcl-2
  • Srebf1 protein, rat
  • Sterol Regulatory Element Binding Protein 1
  • bcl-2-Associated X Protein
  • fas Receptor