Static and dynamic characteristics of cerebral blood flow during the resting state

Neuroimage. 2009 Nov 15;48(3):515-24. doi: 10.1016/j.neuroimage.2009.07.006. Epub 2009 Jul 14.


In this study, the static and dynamic characteristics of cerebral blood flow (CBF) in the resting state were investigated using an arterial spin labeling (ASL) perfusion imaging technique. Consistent with previous PET results, static CBF measured by ASL was significantly higher in the posterior cingulate cortex (PCC), thalamus, insula/superior temporal gyrus (STG) and medial prefrontal cortex (MPFC) than the average CBF of the brain. The dynamic measurement of CBF fluctuations showed high correlation (functional connectivity) between components in the default mode network. These brain regions also had high local temporal synchrony and high fluctuation amplitude, as measured by regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) analyses. The spatial pattern of the static CBF correlated well with that of the dynamic indices. The high static and dynamic activities in the PCC, MPFC, insula/STG and thalamus suggest that these regions play a vital role in maintaining and facilitating fundamental brain functions.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Brain / blood supply*
  • Brain / physiology*
  • Brain Mapping
  • Cerebrovascular Circulation / physiology*
  • Female
  • Humans
  • Kinetics
  • Magnetic Resonance Imaging
  • Male
  • Perfusion Imaging
  • Rest / physiology*
  • Spin Labels


  • Spin Labels