Early molecular events in PAMP-triggered immunity

Curr Opin Plant Biol. 2009 Aug;12(4):414-20. doi: 10.1016/j.pbi.2009.06.003. Epub 2009 Jul 14.


In plant innate immunity, the first line of microbial recognition leading to active defence responses relies on the perception of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs). This recognition leads to PAMP-triggered immunity (PTI). Despite the numerous PAMPs recognised by plants, only a handful of PRRs are characterised. For most, they correspond to transmembrane proteins with a ligand-binding ectodomain. PRRs interact with additional transmembrane proteins that act as signalling adapters or amplifiers to achieve full functionality. The crucial role of PRRs in anti-microbial immunity is demonstrated by the direct targeting of PRRs and their associated proteins by pathogenic virulence effectors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Host-Pathogen Interactions
  • Immunity, Innate
  • Membrane Proteins / metabolism*
  • Models, Biological
  • Plant Diseases / microbiology
  • Plant Proteins / metabolism*
  • Plants / metabolism*
  • Plants / microbiology
  • Protein Binding
  • Receptors, Pattern Recognition / metabolism*
  • Signal Transduction


  • Membrane Proteins
  • Plant Proteins
  • Receptors, Pattern Recognition