The effect of intravenous alanyl-glutamine supplementation on plasma glutathione levels in intensive care unit trauma patients receiving enteral nutrition: the results of a randomized controlled trial

Anesth Analg. 2009 Aug;109(2):502-5. doi: 10.1213/ane.0b013e3181a83178.


Background: We sought to investigate the effect of IV alanyl-glutamine supplementation on plasma glutathione levels in severely traumatized patients receiving enteral nutrition.

Methods: Forty adult patients with severe trauma according to the Injury Severity Score >20 were enrolled in this randomized, controlled study. The patients were assigned to two groups: Group G received 0.5 g x kg(-1) x d(-1) of alanyl-glutamine dipeptide supplementation IV, and Group C received a control solution without alanyl-glutamine for 7 days. Blood samples were taken for analysis of glutathione before the initiation of supplementation and on the 3rd, 7th, and 10th days of feeding.

Results: Total plasma glutathione levels significantly increased in Group G when compared with Group C on Days 7 and 10 (1.34 +/- 0.20 microM vs 1.13 +/- 0.14 microM, and 1.38 +/- 0.19 microM vs 1.12 +/- 0.16 microM) (P < 0.001).

Conclusions: This study demonstrates that IV alanyl-glutamine supplementation for 7 days increases total plasma glutathione levels in critically ill trauma patients receiving standard enteral nutrition.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Critical Care
  • Critical Illness
  • Cross Infection / epidemiology
  • Dipeptides / pharmacokinetics*
  • Enteral Nutrition*
  • Female
  • Glutathione / blood*
  • Humans
  • Intensive Care Units
  • Male
  • Middle Aged
  • Wounds and Injuries / blood*
  • Wounds and Injuries / therapy
  • Young Adult


  • Dipeptides
  • Glutathione
  • alanylglutamine