Staphylococcus epidermidis--the 'accidental' pathogen

Nat Rev Microbiol. 2009 Aug;7(8):555-67. doi: 10.1038/nrmicro2182.


Although nosocomial infections by Staphylococcus epidermidis have gained much attention, this skin-colonizing bacterium has apparently evolved not to cause disease, but to maintain the commonly benign relationship with its host. Accordingly, S. epidermidis does not produce aggressive virulence determinants. Rather, factors that normally sustain the commensal lifestyle of S. epidermidis seem to give rise to additional benefits during infection. Furthermore, we are beginning to comprehend the roles of S. epidermidis in balancing the epithelial microflora and serving as a reservoir of resistance genes. In this Review, I discuss the molecular basis of the commensal and infectious lifestyles of S. epidermidis.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Biofilms / growth & development
  • Drug Resistance / genetics
  • Host-Pathogen Interactions
  • Humans
  • Skin / microbiology*
  • Staphylococcal Infections / microbiology*
  • Staphylococcus epidermidis / drug effects
  • Staphylococcus epidermidis / pathogenicity*
  • Staphylococcus epidermidis / physiology*
  • Virulence


  • Anti-Bacterial Agents