[Modification of tear film break-up time by beta blocker eyedrops without preservatives]

Klin Monbl Augenheilkd. 1991 Aug;199(2):75-8. doi: 10.1055/s-2008-1046051.
[Article in German]


Traditional beta-blocking eye drops preserved with benzalkonium chloride show an adverse effect on the precorneal tear film, which can be measured by checking the break-up-time (BUT). To decide, whether this adverse effect is caused more by the beta-blocking drug or the preservative, we tested the influence of timolol eye drops without preservative in single dose units Timosine) on the BUT in a prospective, open study. These eyedrops caused no significant shortening of the BUT in persons, which where untreated before. Patients using preserved beta-blocking eye drops and having irritations of their eyes showed significant prolongation of the BUT after changing the therapy to Timosine. Preservative-free beta-blocking eye drops are a real improvement in the therapy of glaucoma patients with irritated eyes.

Publication types

  • English Abstract

MeSH terms

  • Glaucoma / drug therapy*
  • Glaucoma / physiopathology
  • Humans
  • Ocular Hypertension / drug therapy*
  • Ocular Hypertension / physiopathology
  • Ophthalmic Solutions
  • Preservatives, Pharmaceutical / adverse effects
  • Tears / drug effects*
  • Tears / physiology
  • Timolol / administration & dosage
  • Timolol / adverse effects*


  • Ophthalmic Solutions
  • Preservatives, Pharmaceutical
  • Timolol