Abstract
ERGIC-53 is a type I transmembrane protein. It includes an N-terminal signal sequence, a carbohydrate recognition domain, which is calcium-dependent and pH-sensitive, a stalk region, a transmembrane domain, and a short cytoplasmic domain; ERGIC-53 mainly acts as a receptor of a limited number of glycoprotein and transports them from ER to ERGIC and Golgi, meanwhile it has a secondary glycoprotein quality control function. Recent research has revealed that UPR, heat shock and VIPL may regulate the expression of ERGIC-53. F5F8D, and some ER storage diseases have relationship with ERGIC-53.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Blood Coagulation Disorders, Inherited / genetics
-
Endoplasmic Reticulum / metabolism
-
Factor V / genetics
-
Factor VIII / genetics
-
Gene Expression Regulation
-
Genes, Recessive
-
Glycoproteins / metabolism
-
Golgi Apparatus / metabolism
-
Mannose-Binding Lectins / chemistry*
-
Mannose-Binding Lectins / genetics
-
Mannose-Binding Lectins / metabolism*
-
Membrane Proteins / chemistry*
-
Membrane Proteins / genetics
-
Membrane Proteins / metabolism*
-
Protein Binding
-
Protein Sorting Signals
-
Protein Structure, Tertiary
-
Protein Transport
-
Vesicular Transport Proteins / metabolism
Substances
-
Glycoproteins
-
LMAN1 protein, human
-
MCFD2 protein, human
-
Mannose-Binding Lectins
-
Membrane Proteins
-
Protein Sorting Signals
-
Vesicular Transport Proteins
-
Factor V
-
Factor VIII