Minisatellite repeat coding as a digital approach to DNA typing

Nature. 1991 Nov 21;354(6350):204-9. doi: 10.1038/354204a0.


Most DNA typing systems used in forensic and legal medicine assay allelic length variation at tandem repetitive DNA regions such as minisatellites. A simple alternative approach that displays patterns of variant repeat units along minisatellite alleles is described here. This produces DNA profiles as extraordinarily variable digital sequences appropriate for forensic investigations, including computer databasing, and for analysing allele diversity and the role of recombination in minisatellite instability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosome Mapping
  • DNA Fingerprinting / methods*
  • DNA Probes
  • DNA, Satellite / analysis*
  • Female
  • Genetic Variation
  • Haplotypes
  • Heterozygote
  • Humans
  • Male
  • Molecular Sequence Data
  • Mutation
  • Polymerase Chain Reaction
  • Repetitive Sequences, Nucleic Acid
  • Sequence Homology, Nucleic Acid


  • DNA Probes
  • DNA, Satellite