Whipple disease of the central nervous system: an unusual occurrence in association with acquired immune deficiency syndrome

J Neurosurg. 2010 May;112(5):983-9. doi: 10.3171/2009.6.JNS0935.


Whipple disease is a multisystem infectious disease caused by Tropheryma whippleii. It commonly affects the CNS and produces neurological symptoms in 10-20% of cases. Central nervous system Whipple disease occurring in patients with AIDS is extremely rare. The authors present a case of a newly diagnosed AIDS patient in whom intracranial Whipple disease was diagnosed by stereotactic brain biopsy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / immunology
  • Adult
  • Blotting, Western
  • CD4 Antigens / immunology
  • Central Nervous System Infections / microbiology
  • Central Nervous System Infections / pathology*
  • Diagnosis, Differential
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Whipple Disease / complications*
  • Whipple Disease / microbiology
  • Whipple Disease / pathology*


  • CD4 Antigens