Morphometry of the human cortex cerebri and corpus striatum during aging

Neurobiol Aging. 1991 Jul-Aug;12(4):336-8; discussion 352-5. doi: 10.1016/0197-4580(91)90013-a.


The commentary is based on our results of biological aging research with the following findings: a loss of neurons cannot be found, the size of neurons and the number of synapses decrease with age, the various regions of brain react quite differently. Altogether, these results speak for "use it or lose it." However, the genetically determined decreased brain function during aging can only be inhibited, not permanently preserved.

Publication types

  • Comment

MeSH terms

  • Aged
  • Aging / physiology*
  • Alzheimer Disease / pathology*
  • Brain / pathology*
  • Cerebral Cortex / pathology*
  • Corpus Striatum / pathology*
  • Humans
  • Longevity