Observer agreement in the diagnosis of serrated polyps of the large bowel

Histopathology. 2009 Jul;55(1):63-6. doi: 10.1111/j.1365-2559.2009.03329.x.


Aims: To assess observer agreement in the diagnosis of colorectal serrated polyps, in particular, serrated adenomas and admixed polyps (i.e. 'polyps with admixed hyperplastic and adenomatous glands').

Methods and results: Sixty cases of large bowel polyps were assessed by four specialist gastrointestinal histopathologists and allocated into one of five categories: serrated adenoma, hyperplastic polyp, conventional adenoma, admixed polyp, and other polyps with serration. Complete agreement amongst all four assessors was seen with only two-fifths of the cases. The overall kappa value for all the assessors distinguishing between all five categories was 0.49. The kappa values for diagnosing serrated adenoma versus all other polyps, and admixed polyp versus all other polyps were 0.38 and 0.3, respectively.

Conclusions: Specialist gastrointestinal histopathologists show only moderate concordance when distinguishing between serrated colorectal polyps. There is only fair interobserver agreement in the diagnosis of serrated adenomas and admixed polyps of the large bowel.

MeSH terms

  • Adenoma / diagnosis*
  • Adenoma / pathology
  • Cohort Studies
  • Colonic Neoplasms / diagnosis*
  • Colonic Neoplasms / pathology
  • Colonic Polyps / diagnosis*
  • Colonic Polyps / pathology
  • Humans
  • Observer Variation
  • Reproducibility of Results
  • Retrospective Studies