A multinational, randomized, placebo-controlled trial to assess the immunogenicity, safety, and tolerability of live attenuated influenza vaccine coadministered with oral poliovirus vaccine in healthy young children

Vaccine. 2009 Sep 4;27(40):5472-9. doi: 10.1016/j.vaccine.2009.07.002. Epub 2009 Jul 17.

Abstract

Live attenuated influenza vaccine (LAIV) provides a useful tool to rapidly immunize populations in the developing world to prevent influenza outbreaks. In this noninferiority trial conducted in Asia and South America, where oral poliovirus vaccine (OPV) is still used, 2503 children aged 6 to <36 months with three polio immunizations were randomized to receive LAIV+OPV, placebo+OPV, or LAIV only. Immune responses in children receiving concomitant LAIV+OPV were noninferior to those observed in recipients of either vaccine alone. Response rates for different poliovirus types were similar in recipients of LAIV+OPV and placebo+OPV. Response rates to all influenza strains were similar in LAIV+OPV and LAIV-only recipients. Concomitant OPV and LAIV were safely administered to young children.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood
  • Child, Preschool
  • Female
  • Humans
  • Immunization Schedule
  • Infant
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / adverse effects
  • Influenza Vaccines / immunology
  • Influenza, Human / prevention & control*
  • Male
  • Poliomyelitis / prevention & control*
  • Poliovirus Vaccine, Oral / administration & dosage*
  • Poliovirus Vaccine, Oral / adverse effects
  • Poliovirus Vaccine, Oral / immunology
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / adverse effects
  • Vaccines, Attenuated / immunology

Substances

  • Antibodies, Viral
  • Influenza Vaccines
  • Poliovirus Vaccine, Oral
  • Vaccines, Attenuated