The genetic and molecular regulation of sleep: from fruit flies to humans

Nat Rev Neurosci. 2009 Aug;10(8):549-60. doi: 10.1038/nrn2683.


It has been known for a long time that genetic factors affect sleep quantity and quality. Genetic screens have identified several mutations that affect sleep across species, pointing to an evolutionary conserved regulation of sleep. Moreover, it has also been recognized that sleep affects gene expression. These findings have given valuable insights into the molecular underpinnings of sleep regulation and function that might lead the way to more efficient treatments for sleep disorders.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Circadian Rhythm / genetics*
  • Drosophila / physiology*
  • Drosophila Proteins / genetics*
  • Gene Expression Regulation*
  • Humans
  • Models, Biological
  • Mutation / genetics
  • Signal Transduction / genetics
  • Sleep / genetics*


  • Drosophila Proteins