Transmissible mink encephalopathy - review of the etiology of a rare prion disease

Folia Neuropathol. 2009;47(2):195-204.


We review here the history, neuropathology, clinical picture and molecular data on transmissible mink encephalopathy (TME). This obscure disease is of utmost importance as it is plausible that it represents a transmission of hidden bovine spongiform encephalopathy (BSE) to mink in the USA. Of special interest is the similarity of L-type of BSE and TME. Furthermore, experimental molecular studies showed the TME strain-specific in vitro conversion in a cell-free system. In addition, we show here for the first time confocal laser microscopy studies of co-localization of PrPd- amyloid plaques and GFAP-expressing astrocytes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cattle
  • Encephalopathy, Bovine Spongiform / genetics
  • Encephalopathy, Bovine Spongiform / pathology
  • Encephalopathy, Bovine Spongiform / transmission
  • Microscopy, Confocal
  • Mink
  • Prion Diseases / genetics
  • Prion Diseases / pathology*
  • Prion Diseases / transmission*
  • Prions / genetics*
  • Prions / metabolism


  • Prions