A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway

Dev Cell. 2009 Jul;17(1):27-34. doi: 10.1016/j.devcel.2009.07.002.

Abstract

The canonical Wnt/beta-catenin pathway is extensively characterized, broadly conserved, and clinically important. In this review, we describe the C. elegans Wnt/beta-catenin asymmetry pathway and suggest that some of its unusual features may have important implications for the canonical Wnt/beta-catenin pathway.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism*
  • Cell Polarity
  • Gene Expression Regulation
  • Humans
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / metabolism
  • Models, Molecular
  • Phylogeny
  • Protein Structure, Tertiary
  • Signal Transduction / physiology*
  • TCF Transcription Factors / genetics
  • TCF Transcription Factors / metabolism*
  • Wnt Proteins / genetics
  • Wnt Proteins / metabolism*
  • beta Catenin / genetics
  • beta Catenin / metabolism*

Substances

  • Caenorhabditis elegans Proteins
  • TCF Transcription Factors
  • Wnt Proteins
  • beta Catenin
  • Mitogen-Activated Protein Kinases
  • nemo-like kinase, zebrafish