Dynamic Causal Modeling applied to fMRI data shows high reliability

Neuroimage. 2010 Jan 1;49(1):603-11. doi: 10.1016/j.neuroimage.2009.07.015. Epub 2009 Jul 18.


Sensitivity, specificity, and reproducibility are vital to interpret neuroscientific results from functional magnetic resonance imaging (fMRI) experiments. Here we examine the scan-rescan reliability of the percent signal change (PSC) and parameters estimated using Dynamic Causal Modeling (DCM) in scans taken in the same scan session, less than 5 min apart. We find fair to good reliability of PSC in regions that are involved with the task, and fair to excellent reliability with DCM. Also, the DCM analysis uncovers group differences that were not present in the analysis of PSC, which implies that DCM may be more sensitive to the nuances of signal changes in fMRI data.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acoustic Stimulation
  • Adolescent
  • Adult
  • Algorithms
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / statistics & numerical data*
  • Male
  • Middle Aged
  • Models, Neurological*
  • Models, Statistical*
  • Photic Stimulation
  • Reproducibility of Results
  • Young Adult