Antiplatelet medications: old and emerging therapies

Ann Vasc Surg. 2010 Jan;24(1):140-8. doi: 10.1016/j.avsg.2009.03.008. Epub 2009 Jul 19.


Antiplatelet medications have been proven to enhance outcomes in patients with cardiovascular disease. The ideal platelet inhibitor would be quick and reversible and would have universal response, an excellent safety profile, and proven benefit. Currently available antiplatelet medications have been demonstrated to have variable patient response. In light of this medication resistance, emerging therapies to inhibit platelet aggregation are under investigation. We review the currently available antiplatelet medications and the current state of these emerging therapies.

Publication types

  • Review

MeSH terms

  • Blood Platelets / drug effects*
  • Blood Platelets / metabolism
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / drug therapy*
  • Drug Resistance
  • Drugs, Investigational / adverse effects
  • Drugs, Investigational / therapeutic use*
  • Humans
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / adverse effects
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Risk Assessment
  • Treatment Outcome


  • Drugs, Investigational
  • Platelet Aggregation Inhibitors