Abstract
A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution from glycine to cysteine at position 238 in comparison to CTX-M-15. This exchange decreased the hydrolytic activity of the beta-lactamase for cefotaxime, ceftazidime, and cefepime.
MeSH terms
-
Anti-Bacterial Agents / pharmacology
-
Bulgaria
-
Cefepime
-
Cefotaxime / pharmacology
-
Ceftazidime / pharmacology
-
Cephalosporins / pharmacology
-
Kinetics
-
Klebsiella pneumoniae / drug effects
-
Klebsiella pneumoniae / enzymology*
-
Klebsiella pneumoniae / genetics
-
Klebsiella pneumoniae / isolation & purification
-
Microbial Sensitivity Tests
-
Molecular Sequence Data
-
beta-Lactamases / genetics*
Substances
-
Anti-Bacterial Agents
-
Cephalosporins
-
Cefepime
-
Ceftazidime
-
beta-Lactamases
-
Cefotaxime