New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria

Antimicrob Agents Chemother. 2009 Oct;53(10):4518-21. doi: 10.1128/AAC.00461-09. Epub 2009 Jul 20.

Abstract

A single Klebsiella pneumoniae strain isolated in a Bulgarian hospital was found to produce CTX-M-71, a new CTX-M variant characterized by one amino acid substitution from glycine to cysteine at position 238 in comparison to CTX-M-15. This exchange decreased the hydrolytic activity of the beta-lactamase for cefotaxime, ceftazidime, and cefepime.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bulgaria
  • Cefepime
  • Cefotaxime / pharmacology
  • Ceftazidime / pharmacology
  • Cephalosporins / pharmacology
  • Kinetics
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / isolation & purification
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Cefepime
  • Ceftazidime
  • beta-Lactamases
  • Cefotaxime

Associated data

  • GENBANK/FJ815436